Exercise ability is determined by muscle ATP buffer content, not Pi or pH

Pi¡ATP flux in exercising human muscle

Alison Sleigh, David B. Savage, Guy B. Williams, David Porter, T. Adrian Carpenter, Kevin M. Brindle, and Graham J. Kemp Wolfson Brain Imaging Centre, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, United Kingdom; National Institute for Health Research/Wellcome Trust Clinical Research Facility at Cambridge University Hospitals NHS Foundation Trust, Cambridge B...

To ATP or Not To ATP: This Is the Question

Correspondence to Alessio Accardi: a l e s s i o a c c a r d i @ u i o w a . e d u The ability to sense the metabolic state of a cell and tune its electrical activity through the direct or indirect modulation of ion transport systems by ATP is essential in a multitude of physiological processes in both excitable and nonexcitable cells. For example in pancreatic cells an increase in the ATP leve...

To ATP or Not To ATP : This Is

Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content.

The purpose of this investigation was to validate that in vivo measurement of skeletal muscle attenuation (MA) with computed tomography (CT) is associated with muscle lipid content. Single-slice CT scans performed on phantoms of varying lipid concentrations revealed good concordance between attenuation and lipid concentration (r(2) = 0.995); increasing the phantom's lipid concentration by 1 g/1...

Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle.

The current dogma is that the muscle adaptation to resistance exercise is blunted when combined with endurance exercise. The suggested mechanism (based on rodent experiments) is that activation of adenosine monophosphate-activated protein kinase (AMPK) during endurance exercise impairs muscle growth through inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). The purpose of thi...